Two general approaches have been taken with Hair Revital X the drug-based approach. The first is the blockade of the androgen precursor enzyme 5 alpha reductase (5AR). Two isoforms of 5AR have been identified, each distinct from the other by pH and tissue localization. Type 2 5AR has long been more strongly linked to pattern hair loss while type 1 5AR was thought to be less important. Recent studies indicate, however, that the molecular biochemistry may be more complex. Although the functional significance of the differential subcellular localization of type 1 and 2 isoenzymes in the hair follicle is currently unknown, the present data suggest that both 5AR isoforms may contribute to phenotype in an additive or synergistic manner.


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